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Cx43、NMDA与大鼠肠易激综合征内脏敏化的关系研究
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Cx43、NMDA与大鼠肠易激综合征内脏敏化的关系研究
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Journal Article
Cx43、NMDA与大鼠肠易激综合征内脏敏化的关系研究
2015
Overview
目的探讨大鼠间隙连接蛋白43（Cx43）和骶髓N-甲基-D-天冬氨酸（NMDA）受体与肠易激综合征（IBS）内脏敏化的关系。方法雄性SD大鼠50只,随机分为正常对照组、正常结肠扩张组、IBS组、IBS结肠扩张组及IBS结肠扩张＋甲磺酸伊马替尼（STI-571）干预组,每组10只。IBS组、IBS结肠扩张组和IBS结肠扩张并干预组大鼠采用旋毛虫感染制作IBS模型。采用免疫荧光组织化学法观察各组大鼠结肠Cx43和骶髓NMDA受体的表达。结果正常组、正常结肠扩张组、IBS组的结肠Cx43和骶髓NMDA表达水平差异无统计学意义（P〉0.05）,IBS结肠扩张组结肠Cx43和骶髓NMDA表达水平与正常组、正常结肠扩张组、IBS组比较均显著增强（P〈0.01）,而STI-571干预后大鼠结肠Cx43和骶髓NMDA表达均有所下降（P〈0.01）。结论 Cx43和NMDA可能在IBS内脏敏化机制中起关键作用。
