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早期腹腔置管引流对大鼠重症急性胰腺炎相关肠黏膜损伤的作用
by
邓超 曹均强 梁鸿寅 陈光宇 刘卫辉 汤礼军 戴睿武
in
引流术
/ 肠黏膜
/ 胰腺炎,急性坏死性
2016
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早期腹腔置管引流对大鼠重症急性胰腺炎相关肠黏膜损伤的作用
by
邓超 曹均强 梁鸿寅 陈光宇 刘卫辉 汤礼军 戴睿武
in
引流术
/ 肠黏膜
/ 胰腺炎,急性坏死性
2016
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Journal Article
早期腹腔置管引流对大鼠重症急性胰腺炎相关肠黏膜损伤的作用
2016
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目的研究早期腹腔置管引流对大鼠重症急性胰腺炎(SAP)相关肠黏膜损伤的保护作用。方法 36只SD大鼠随机分为对照组、模型组(SAP组)、早期腹腔置管引流组(APD组),每组12只。向胰胆管以12ml/h的速度注入5%牛磺胆酸钠(0.1ml/100g),制作大鼠SAP模型。造模后24h处死,观察并对比各组大鼠腹腔内大体改变,HE染色观察小肠病理改变并评分,ELISA法测定大鼠血清中肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)、二胺氧化酶(DAO)及D-乳酸水平。结果与对照组比较,SAP组、APD组小肠组织病理学评分,血清TNF-α、IL-1β、二胺氧化酶及D-乳酸水平均显著升高(P〈0.05);与SAP组比较,APD组上述各项指标均显著降低(P〈0.05)。结论早期腹腔置管引流能有效改善SAP大鼠模型肠黏膜损伤程度,减轻机体全身炎症反应。
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