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模拟微重力对猕猴脾脏结构、脾脏免疫细胞及其细胞因子表达的影响
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Journal Article
模拟微重力对猕猴脾脏结构、脾脏免疫细胞及其细胞因子表达的影响
2016
Overview
目的探讨模拟微重力对猕猴脾脏结构及免疫细胞表面分子和相关细胞因子表达的影响。方法在特殊装置上将猕猴置于头低位–10°以模拟微重力。将15只猕猴随机均分为对照组（NC组）、模拟微重力组（SM组）和模拟微重力后恢复组（MR组）,每组5只。完成实验后,猕猴在麻醉状态下放血处死,取脾脏组织标本进行HE和免疫组化染色。观察各组猕猴脾脏大体结构,检测脾脏免疫细胞表面分子CD3、CD4、CD8、CD20、CD68及相关细胞因子（IL-1β、IL-5、IL-6、IL-17、IL-18、IL-22、IL-23）的表达。结果 NC组脾脏组织结构正常,SM组脾脏红、白髓分界不清,白髓缩小,动脉周围淋巴鞘减小,淋巴细胞排列紊乱,MR组改变较SM组轻。免疫组化结果显示,与NC组和MR组比较,SM组脾脏表达CD3^＋、CD4^＋、CD20^＋的免疫细胞数目降低,CD8＋免疫细胞数目增高,IL-5分泌水平降低,差异有统计学意义（P〈0.05）。结论模拟微重力可引起猕猴脾脏组织结构损伤,对CD3^＋T细胞、CD4^＋T细胞、CD8^＋T细胞和CD20＋B细胞数目有一定影响,并能影响细胞因子IL-5分泌,这可能与模拟微重力引起免疫系统功能受损有关。
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