Asset Details
Do you wish to reserve the book?
炎症激活间充质干细胞源微泡对糖尿病慢性创面愈合的促进作用观察
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
炎症激活间充质干细胞源微泡对糖尿病慢性创面愈合的促进作用观察
Do you wish to request the book?
炎症激活间充质干细胞源微泡对糖尿病慢性创面愈合的促进作用观察
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
炎症激活间充质干细胞源微泡对糖尿病慢性创面愈合的促进作用观察
2016
Overview
目的探讨炎症激活条件下间充质干细胞分泌的微泡（LPS-exosomes）对糖尿病慢性创面的治疗作用。方法用终浓度为100ng/ml的脂多糖预处理间充质干细胞2d,收集上清液,利用超速梯度离心法分离提取微泡,并对其进行鉴定。建立糖尿病大鼠皮肤缺损模型,将实验大鼠随机分为3组：未治疗组、间充质干细胞源微泡治疗组、炎症激活间充质干细胞源微泡治疗组,分次多点注射微泡60μg于伤口周边,1次/d,连续10d。于治疗后第3、7、14天进行创面大体观察,q RT-PCR法检测创面炎症相关因子表达水平及巨噬细胞亚型表面标记物的表达改变。结果与未治疗组相比,炎症激活间充质干细胞源微泡治疗组创面愈合速度明显加快,治疗后第7、14天促炎因子IL-1、IL-12及M1型巨噬细胞表面标记物i NOS表达水平明显降低,同时抗炎因子IL-10、TGF-β及M2型巨噬细胞表面标记物CD163表达明显增加,差异均有统计学意义（P〈0.05）。结论炎症激活间充质干细胞源微泡可能通过调节巨噬细胞表型改变,抑制创面局部慢性炎症反应,进而加速糖尿病皮肤创面的愈合。
We currently cannot retrieve any items related to this title. Kindly check back at a later time.