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艾灸刺激对腓总神经横断术后胃黏膜损伤修复的影响
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艾灸刺激对腓总神经横断术后胃黏膜损伤修复的影响
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Journal Article
艾灸刺激对腓总神经横断术后胃黏膜损伤修复的影响
2017
Overview
目的：探讨艾灸启动内源性保护信息对胃黏膜的保护效应与腓总神经通路的关系。方法：将48只SpragueDawley（SD）大鼠随机分为正常组（A组）,模型组（B组）,艾灸模型组（C组）和艾灸模型手术组（D组）,每组12只。除A组外,其余各组用无水乙醇、阿司匹林灌胃制备胃黏膜损伤模型。B组不予治疗干预;C组予艾灸足三里治疗,每日2次,连续治疗3 d;D组进行腓总神经切断术后制备胃黏膜损伤模型,予以艾灸足三里治疗。干预3 d后观察各组胃黏膜损伤指数（UI）,并进行胃黏膜相关修复细胞因子肿瘤坏死因子-α（TNF-α）、白介素-4（IL-4）和热休克蛋白70（HSP70）检测。结果：与A组相比,B组病理及UI改变较差（P=0.000）;血清与组织中TNF-α改变明显（P=0.000,P=0.002）;血清与组织中IL-4改善明显（P=0.000,P=0.000）。与B组相比,C组和D组TNF-α与IL-4改善明显（TNF-α：P=0.003,P=0.016;IL-4：P=0.000,P=0.002）。与C组比较,B组和D组UI改变效果较差（均P=0.000）;血清中TNF-α与IL-4下降明显（TNF-α：P=0.000,P=0.025;IL-4：P=0.000,P=0.034）;组织中HSP70值下降明显（P=0.000,P=0.033）。结论：足三里穴可通过腓总神经途径传递信息,调节胃黏膜保护因子的释放,并上调细胞修复相关蛋白表达,从而达到修复胃黏膜的效应。
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