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Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke
by
MinKyun Na
, Jong Seog Ahn
, Seung Ho Lee
, Eun Young Bae
, In Hyun Hwang
, Bo Yeon Kim
, Ji Young Choi
in
Betulinic acid
/ Betulinic acid methyl ester
/ Dehydrocostuslactone
/ Mokko lactone
/ Protein tyrosine phosphatase 1B
/ Saussurea lappa C.B.Clarke
2009
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Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke
by
MinKyun Na
, Jong Seog Ahn
, Seung Ho Lee
, Eun Young Bae
, In Hyun Hwang
, Bo Yeon Kim
, Ji Young Choi
in
Betulinic acid
/ Betulinic acid methyl ester
/ Dehydrocostuslactone
/ Mokko lactone
/ Protein tyrosine phosphatase 1B
/ Saussurea lappa C.B.Clarke
2009
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Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke
by
MinKyun Na
, Jong Seog Ahn
, Seung Ho Lee
, Eun Young Bae
, In Hyun Hwang
, Bo Yeon Kim
, Ji Young Choi
in
Betulinic acid
/ Betulinic acid methyl ester
/ Dehydrocostuslactone
/ Mokko lactone
/ Protein tyrosine phosphatase 1B
/ Saussurea lappa C.B.Clarke
2009
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Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke
Journal Article
Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke
2009
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Overview
Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors.
Publisher
MDPI AG
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