Journal Article

EEG–Metabolic Coupling and Time Limit at O2max During Constant-Load Exercise

Emmanuel Maby, Bertrand Massot, Lesly Fornoni, Thomas Creveaux, François Rigaud, Michel Clémençon, Cécilia Damon, Marie Brandewinder, Véronique Billat, Alexis Bénichoux, Luc Poinsard, Slim Essid, Patrick Bouchet, Vincent Pialoux, Jérémie Mattout, Pascal Van Beers, Christian Collet, Christian Berthomier, Patrice Revol

2025

Overview

Background: Exercise duration at maximum oxygen uptake ( V ˙ O2max) appears to be influenced not only by metabolic factors but also by the interplay between brain dynamics and ventilatory regulation. This study examined how cortical activity, assessed via electroencephalography (EEG), relates to performance and acute fatigue regulation during a constant-load cycling test. We hypothesized that oscillatory activity in the theta, alpha, and beta bands would be associated with ventilatory coordination and endurance capacity. Methods: Thirty trained participants performed a cycling test to exhaustion at 90% maximal aerobic power. EEG and gas exchange were continuously recorded; ratings of perceived exertion were assessed immediately after exhaustion. Results: Beta power was negatively correlated with time spent at V ˙ O2max (r = −0.542, p = 0.002). Theta and Alpha power alone showed no direct associations with endurance, but EEG–metabolic ratios revealed significant correlations. Specifically, the time to reach V ˙ O2max correlated with Alpha/ V ˙ O2 (p < 0.001), Alpha/ V ˙ CO2 (p < 0.001), and Beta/ V ˙ CO2 (p = 0.002). The time spent at V ˙ O2max correlated with Theta/ V ˙ O2 (p = 0.002) and Theta/ V ˙ CO2 (p < 0.001). The time-to-exhaustion was correlated with Theta/ V ˙ CO2 (p < 0.001) and Alpha/ V ˙ CO2 (p < 0.001). Conclusions: These findings indicate that cortical oscillations were associated with different aspects of acute fatigue regulation. Beta activity was associated with fatigue-related neural strain, whereas Theta and Alpha bands, when normalized to metabolic load, were consistent with a role in ventilatory coordination and motor control. EEG–metabolic ratios may provide exploratory indicators of brain–metabolism interplay during high-intensity exercise and could help guide future brain-body interactions in endurance performance.

• Publisher: MDPI AG
• Subject: V ˙ O2max / electroencephalography / endurance / exhaustion / high-intensity exercise / time limit