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Parathyroid hormone in pediatric patients with B-thalassemia major and its relation to bone mineral density : a case control study
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Parathyroid hormone in pediatric patients with B-thalassemia major and its relation to bone mineral density : a case control study
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Journal Article
Parathyroid hormone in pediatric patients with B-thalassemia major and its relation to bone mineral density : a case control study
2017
Overview
Background : Thalassemia syndromes are heterogeneous groups of inherited anemias. Its
treatment depends on recurrent blood transfusion with a problem of iron overload, which leads to
multiple endocrinopathies including hypoparathyroid. The aim of the study is to estimate the level
of serum parathyroid hormone and its relation to bone mineral density in transfusion dependent
beta-thalassemia major children.
Subjects and methods : We measured serum calcium, phosphorus and parathyroid hormone in a
sample of pediatric patients with thalassemia, compared them with age and sex matched healthy
control. Measurement of bone mineral density by dual-energy X-ray absorptiometry was done in
2 sites : lumbar spine (L2–L4) in the anteroposterior position and left femur neck using Lunar Densitometry
in osteoporosis Unit Ain Shams University Hospital for thalassemia patients.
Results : Thalassemic patients had significantly higher alkaline phosphatase and lower bone mineral
density.
Conclusion : Osteopenia in b-thalassemia major patients is multifactorial and is mainly predisposed
by defective function of the parathyroid gland and excessive iron deposition
Publisher
Egyptian Society of Human Genetics
Subject
