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Journal Article
The type IV secretion system in
2018
Overview
(
) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, the
pathogenicity island, which is a type IV secretion system (T4SS) to deliver CagA into the host cells. Besides
-T4SS, the chromosomes of
can encode another three T4SSs, including
,
and
. In this review, we systematically reviewed the four T4SSs of
and explored their roles in the pathogenesis of gastroduodenal diseases. The information summarized in this review might provide valuable insights into the pathogenic mechanism for
.
Publisher
Future Medicine Ltd
Subject
