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Misoprostol-induced fever and genetic polymorphisms in drug transporters

by Curley, Paul , Box, Helen , Elati, Anisa , Pirmohamed, Munir , Zhang, J Eunice , Xinarianos, George , Weeks, Andrew , Durocher, Jill , Siccardi, Marco , Winikoff, Beverly , Rädisch, Steffen , Dickens, David , Alfirevic, Ana , Owen, Andrew , Alfirevic, Zarko , León, Wilfrido , Ardeshana, Arjun

in adverse drug reactions / drug transporters / misoprostol / misoprostol-induced fever / obstetrics / pharmacogenetics / postpartum hemorrhage / reproductive medicine

2015

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Misoprostol-induced fever and genetic polymorphisms in drug transporters

in adverse drug reactions / drug transporters / misoprostol / misoprostol-induced fever / obstetrics / pharmacogenetics / postpartum hemorrhage / reproductive medicine

2015

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Misoprostol-induced fever and genetic polymorphisms in drug transporters

in adverse drug reactions / drug transporters / misoprostol / misoprostol-induced fever / obstetrics / pharmacogenetics / postpartum hemorrhage / reproductive medicine

2015

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Journal Article

Misoprostol-induced fever and genetic polymorphisms in drug transporters

Curley, Paul,

Box, Helen,

Elati, Anisa,

Pirmohamed, Munir,

Zhang, J Eunice,

Xinarianos, George,

Weeks, Andrew,

Durocher, Jill,

Siccardi, Marco,

Winikoff, Beverly,

Rädisch, Steffen,

Dickens, David,

Alfirevic, Ana,

Owen, Andrew,

Alfirevic, Zarko,

León, Wilfrido,

Ardeshana, Arjun

2015

Overview

Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic susceptibility may play a role in misoprostol-induced fever. Body temperature of women treated with misoprostol for termination of pregnancy in the UK (n = 107) and for postpartum hemorrhage in Ecuador (n = 50) was measured. Genotyping for 33 single nucleotide polymorphisms in 15 candidate genes was performed. Additionally, we investigated the transport of radiolabeled misoprostol acid across biological membranes . The single nucleotide polymorphism rs11568658 was associated with misoprostol-induced fever. Misoprostol acid was transported across a blood-brain barrier model by MRP4 and SLCO1B1. Genetic variability in ABCC4 may contribute to misoprostol-induced fever in pregnant women. Original submitted 21 January 2015; Revision submitted 24 April 2015

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Publisher

Future Medicine Ltd

Subject

adverse drug reactions

/ drug transporters

/ misoprostol

/ misoprostol-induced fever

/ obstetrics

/ pharmacogenetics

/ postpartum hemorrhage