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Journal Article
Polymorphisms in
2016
Overview
Sorafenib-treated patients display a substantial variation in the incidence of toxicity. We aimed to investigate the association of genetic polymorphisms with observed toxicity on sorafenib.
We genotyped 114 patients that were treated with sorafenib at the Erasmus MC Cancer Institute, the Netherlands, for
and
.
The
(rs8175347) polymorphism was associated with hyperbilirubinemia and treatment interruption. Polymorphisms in
(rs2306283, rs4149056) were associated with diarrhea and thrombocytopenia, respectively. None of the investigated polymorphisms was associated with overall or progression-free survival in hepatocellular cancer patients.
Polymorphisms in
and
are associated with several different sorafenib side effects.
Publisher
Future Medicine Ltd
Subject
