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Journal Article
Impact of
2018
Overview
This study aimed to assess the impact of
and
variation on venlafaxine (VEN) at steady state in patients from Trinidad and Tobago of Indian and African descent with major depressive disorder.
Patients were phenotyped with dextromethorphan, genotyped for
and
, and metabolic ratios for VEN obtained at 2-week intervals.
Of 61 patients, 55 were genotyped and phenotyped and 47 completed 8 weeks of VEN treatment. The majority of patients had metabolic ratios for VEN that were consistent with those for dextromethorphan and genotype-predicted phenotype using activity scores. One subject presented with a novel no-function allele,
. No correlations were observed with
genotype.
genotype analysis provides valuable information to individualize drug therapy with VEN.
Publisher
Future Medicine Ltd
Subject
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