Asset Details
MbrlCatalogueTitleDetail
Do you wish to reserve the book?
Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel
by
Wang, Wen-hui
, Cheng, Cui-cui
, Lu, Jia
, He, Wan-hong
, Zhang, Wang-dong
, Liu, Lei
, Chen, Zhi-hua
in
Immunoglobulin A
2022
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
You are currently in the queue to collect this book. You will be notified once it is your turn to collect the book.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Oops! Something went wrong.
While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel
by
Wang, Wen-hui
, Cheng, Cui-cui
, Lu, Jia
, He, Wan-hong
, Zhang, Wang-dong
, Liu, Lei
, Chen, Zhi-hua
in
Immunoglobulin A
2022
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel
Journal Article
Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel
2022
Request now
and choose the collection method
Overview
Polymeric immunoglobulin receptor (pIgR), the transmembrane transporter of polymeric immunoglobulin A and M, has multiple immune functions. To explore the characteristics of pIgR expression in Bactrian camel lungs, twelve healthy adult (2-7 years old) Bactrian camels were systematically studied. The results showed that pIgR was mainly expressed in the cytoplasm and membrane of ciliated cells, as well as in the cytoplasm and membrane of basal cells, serous cells of bronchial glands, club cells and alveolar type 2 cells in Bactrian camel lungs. Specially, as the bronchial branches extended, the pIgR expression level in ciliated cells significantly declined (p<0.05), and the corresponding bronchial luminal areas obviously decreased (p<0.05). However, pIgR was not expressed in goblet cells, endocrine cells, alveolar type 1 cells and mucous cells of bronchial glands. The results demonstrated that ciliated cells continuously distributed throughout the whole bronchial tree mucosa were the major expression sites of pIgR, and pIgR was also expressed in basal cells, serous cells of bronchial glands, club cells and alveolar type 2 cells, which would facilitate secretory immunoglobulin A (SIgA) transmembrane transport by pIgR and form an intact protective barrier. Moreover, the pIgR expression level in ciliated cells was positively correlated with the bronchial luminal areas; but negatively correlated with the cleanliness of airflow through the bronchial cross-sections, showing that the pIgR expression level in the bronchial epithelium was inhomogeneous. Our study provided a foundation for further exploring the regulatory functions of immunoglobulins (i.e., SIgA) after transport across the membrane by pIgR in Bactrian camel lungs.
Publisher
Public Library of Science
Subject
This website uses cookies to ensure you get the best experience on our website.