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Receptor binding by a ferret-transmissible H5 avian influenza virus
by
Xiong, Xiaoli
, Martin, Stephen R.
, Liu, Junfeng
, Xiao, Haixia
, Locher, Kathrin
, McCauley, John W.
, Coombs, Peter J.
in
Algorithms
/ Avian influenza viruses
/ Cell receptors
/ Disease transmission
/ Distribution
/ Ferrets
/ Health aspects
/ Observations
/ Physiological aspects
2013
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Receptor binding by a ferret-transmissible H5 avian influenza virus
by
Xiong, Xiaoli
, Martin, Stephen R.
, Liu, Junfeng
, Xiao, Haixia
, Locher, Kathrin
, McCauley, John W.
, Coombs, Peter J.
in
Algorithms
/ Avian influenza viruses
/ Cell receptors
/ Disease transmission
/ Distribution
/ Ferrets
/ Health aspects
/ Observations
/ Physiological aspects
2013
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Do you wish to request the book?
Receptor binding by a ferret-transmissible H5 avian influenza virus
by
Xiong, Xiaoli
, Martin, Stephen R.
, Liu, Junfeng
, Xiao, Haixia
, Locher, Kathrin
, McCauley, John W.
, Coombs, Peter J.
in
Algorithms
/ Avian influenza viruses
/ Cell receptors
/ Disease transmission
/ Distribution
/ Ferrets
/ Health aspects
/ Observations
/ Physiological aspects
2013
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Receptor binding by a ferret-transmissible H5 avian influenza virus
Journal Article
Receptor binding by a ferret-transmissible H5 avian influenza virus
2013
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Overview
Building on previous work that identified a mutant avian H5 virus that is transmissible between ferrets, the authors present an algorithm to predict virus avidity from the affinity of single haemagglutinin (HA)-receptor interactions; these studies predict that the mutant has a 200-fold preference for the human over the avian receptor, and crystal structures of the mutant HA in complex with human and avian receptors shed light on the molecular basis for these altered binding properties.
Publisher
Nature Publishing Group
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