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Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
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Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
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Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
Journal Article

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

2015
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Overview
Inducible genetic labelling of haematopoietic stem cells (HSCs) and linked mathematical modelling show that at least 30% of all HSCs are productive, and that adult haematopoiesis is largely sustained by 'short-term' downstream stem cells that operate near self-renewal in the steady state; HSC fate mapping provides a quantitative model for better understanding of HSC functions in health and disease.

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