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Identification of a New Delhi metallo-beta-lactamase-4 -producing Escherichia coli in Italy
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Identification of a New Delhi metallo-beta-lactamase-4 -producing Escherichia coli in Italy
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Journal Article
Identification of a New Delhi metallo-beta-lactamase-4 -producing Escherichia coli in Italy
2014
Overview
During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla.sub.NDM-4 gene were investigated. The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and [beta]-lactams. The strains produced the NDM-4 carbapenemase and the bla.sub.NDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.
Publisher
BioMed Central Ltd
Subject
