Journal Article

SYMPTOM AND BIOLOGICAL PROFILES OF LEUKEMIA PATIENTS DURING CHEMOTHERAPY: PRELIMINARY RESULTS

Saligan, L., Lukkahatai, N., Naydonova, T., Ikeda, A., Barcelo, J.D., Tejada, M., Ogburn, T.

2022

Overview

With successful treatment, the survival rate in Leukemia children is increasing, the effect of treatment related symptoms adverse on the health related quality of life is increasingly relevant. However, the etiology of these symptoms is unknown. The study aims to understand symptoms profile and potential biological correlates of children with leukemia during chemotherapy. This preliminary report is a part of an active IRB approved research protocol. Children age 5-21 diagnosed with Leukemia were recruited into the study. A Patient Reported Outcome Measurement Information System (PROMIS) questionnaire and blood sample were collected at before starting chemotherapy and second visit chemotherapy. Data was analyzed by SPSS version 22. Ten participants age 5-16 years old (6 boys and 4 girls) diagnosed with B cell Acute Lymphoblastic Leukemia (ALL) were included in this preliminary analysis. Participants were receiving chemotherapy in the maintenance and consolidation phase. PROMIS score showed participants experienced decreasing of anxiety and depression, increasing of fatigue and no change of pain severity from baseline to the second visit. Laboratory result showed a significant increase of creatinine, cholesterol, and triglyceride at the second visit (p <0.05). At the second visit, boys reported significant lower depression score (38.67 [+ or -] 2.4) than girls (46.35 [+ or -] 6.8) (p =0.03). This preliminary result open an interesting discussion on the potential involvement of lipid homeostasis in treatment related symptoms. This finding is a basis for future studies for an appropriate measurement of the children experiences and biological correlates of symptoms.

• Publisher: Springer
• Subject: Analysis / Child psychopathology / Health aspects