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Fibrinolytic and antibiotic treatment of prosthetic vascular graft infections in a novel rat model
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Fibrinolytic and antibiotic treatment of prosthetic vascular graft infections in a novel rat model
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Journal Article
Fibrinolytic and antibiotic treatment of prosthetic vascular graft infections in a novel rat model
2023
Overview
We developed a rat model of prosthetic vascular graft infection to assess, whether the fibrinolytic tissue plasminogen activator (tPA) could increase the efficacy of antibiotic therapy. Rats were implanted a polyethylene graft in the common carotid artery, pre-inoculated with approx. 6 log.sup.10 colony forming units (CFU) of methicillin resistant Staphylococcus aureus. Ten days after surgery, rats were randomized to either: 0.9% NaCl (n = 8), vancomycin (n = 8), vancomycin + tPA (n = 8), vancomycin + rifampicin (n = 18) or vancomycin + rifampicin + tPA (n = 18). Treatment duration was seven days. Approximately 36 hours after the end of treatment, the rats were euthanized, and grafts and organs were harvested for CFU enumeration. All animals in the control group had significantly higher CFU at the time of euthanization compared to bacterial load found on the grafts prior to inoculation (6.45 vs. 4.36 mean log.sup.10 CFU/mL, p = 0.0011), and both the procedure and infection were well tolerated. We developed the first functional model of an arterial prosthetic vascular graft infection in rats. Antibiotic combination therapy with vancomycin and rifampicin was superior to vancomycin monotherapy, and the addition of tPA did not significantly reduce bacterial load, nor significantly increase cure rate.
Publisher
Public Library of Science
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