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Post-testicular sperm maturation, infertility and hypercholesterolaemia
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Post-testicular sperm maturation, infertility and hypercholesterolaemia
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Journal Article
Post-testicular sperm maturation, infertility and hypercholesterolaemia
2015
Overview
Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia) affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa.
Publisher
Wolters Kluwer – Medknow
