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Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
by Vanhaesebroeck, B. , Macdougall, L. , Koga, H. , Stein, R. , Gout, I. , Wetzker, R. , Panayotou, G. , Linacre, J. , Panaretou, C. , Zvelebil, Markéta J. J. , Waterfield, Michael Derek , Volinia, S. , Domin, J. , Pages, F. , Leevers, S. , Marshall, Christopher John , Salim, K. , Das, P.
1996
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Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
by Vanhaesebroeck, B. , Macdougall, L. , Koga, H. , Stein, R. , Gout, I. , Wetzker, R. , Panayotou, G. , Linacre, J. , Panaretou, C. , Zvelebil, Markéta J. J. , Waterfield, Michael Derek , Volinia, S. , Domin, J. , Pages, F. , Leevers, S. , Marshall, Christopher John , Salim, K. , Das, P.
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1996
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Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
by Vanhaesebroeck, B. , Macdougall, L. , Koga, H. , Stein, R. , Gout, I. , Wetzker, R. , Panayotou, G. , Linacre, J. , Panaretou, C. , Zvelebil, Markéta J. J. , Waterfield, Michael Derek , Volinia, S. , Domin, J. , Pages, F. , Leevers, S. , Marshall, Christopher John , Salim, K. , Das, P.
1996

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Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases
Journal Article

Current understanding of intracellular signalling pathways - Structural and functional diversity of phosphoinositide 3-kinases

Vanhaesebroeck, B.,
Macdougall, L.,
Koga, H.,
Stein, R.,
Gout, I.,
Wetzker, R.,
Panayotou, G.,
Linacre, J.,
Panaretou, C.,
Zvelebil, Markéta J. J.,
Waterfield, Michael Derek,
Volinia, S.,
Domin, J.,
Pages, F.,
Leevers, S.,
Marshall, Christopher John,
Salim, K.,
Das, P.
1996
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Overview
Phosphoinositide 3-kinases (PI3-kinases) have been shown to be recruited to cell surface receptor signal complexes whose form ation is triggered by growth factors, cytokines and other ligands. P13-kinases are also involved in protein sorting phenom ena. A num ber of P13-kinase isotypes have been characterised in several laboratories. H ere the relations between the P13-kinases, P14-kinases and P15-kinases and other potential phosphoinositide kinases are analysed. A study of the relation of structure to function for sequence motifs defined through the use of homology searches and protein m odelling techniques is described and used to assign the family of phosphoinositide kinases to subgroups.
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The Royal Society

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