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Xistimprinting is promoted by the hemizygous (unpaired) state in the male germ line
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Xistimprinting is promoted by the hemizygous (unpaired) state in the male germ line
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Journal Article
Xistimprinting is promoted by the hemizygous (unpaired) state in the male germ line
2015
Overview
The long noncoding X-inactivation–specific transcript (Xistgene) is responsible for mammalian X-chromosome dosage compensation between the sexes, the process by which one of the two X chromosomes is inactivated in the female soma.Xistis essential for both the random and imprinted forms of X-chromosome inactivation. In the imprinted form,Xistis paternally marked to be expressed in female embryos. To investigate the mechanism ofXistimprinting, we introduceXisttransgenes (Tg) into the male germ line. Although ectopic high-levelXistexpression on autosomes can be compatible with viability, transgenic animals demonstrate reduced fitness, subfertility, defective meiotic pairing, and other germ-cell abnormalities. In the progeny, paternal-specific expression is recapitulated by the 200-kbXistTg. However,Xistimprinting occurs efficiently only when it is in an unpaired or unpartnered state during male meiosis. When transmitted from a hemizygous father (+/Tg), theXistTg demonstrates paternal-specific expression in the early embryo. When transmitted by a homozygous father (Tg/Tg), the Tg fails to show imprinted expression. Thus,Xistimprinting is directed by sequences within a 200-kb X-linked region, and the hemizygous (unpaired) state of theXistregion promotes its imprinting in the male germ line.
Publisher
National Academy of Sciences
Subject
