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A Pandrug-Resistant Providencia Carrying Two bla IMP Carbapenemase-Encoding Genes Including bla IMP-69, a New bla IMP Variant, on a Newly Identified Worldwide-Distributed IncC Plasmid
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A Pandrug-Resistant Providencia Carrying Two bla IMP Carbapenemase-Encoding Genes Including bla IMP-69, a New bla IMP Variant, on a Newly Identified Worldwide-Distributed IncC Plasmid
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A Pandrug-Resistant Providencia Carrying Two bla IMP Carbapenemase-Encoding Genes Including bla IMP-69, a New bla IMP Variant, on a Newly Identified Worldwide-Distributed IncC Plasmid
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Journal Article
A Pandrug-Resistant Providencia Carrying Two bla IMP Carbapenemase-Encoding Genes Including bla IMP-69, a New bla IMP Variant, on a Newly Identified Worldwide-Distributed IncC Plasmid
2020
Overview
Imipenemase (IMP) is a metallo-β-lactamase that confers resistance to almost all β-lactams. Identification of IMP genes is essential for understanding and combatting antibiotic resistance. In this study, we report a pandrug-resistant Providencia strain from a human rectal swab. This strain carried 2 bla
IMP carbapenemase genes, bla
IMP-69 and bla
IMP-4. IMP-69 is a novel IMP variant with an amino acid substitution at A21T compared with IMP-8. bla
IMP-69 was found in a bla
IMP-69-aacA4 array of an integron on a 165-kilobase (kb) IncC self-transmissible plasmid, whereas bla
IMP-4 was located in a bla
IMP-4-qacG-aacA4-catB3 array of an integron on a 19-kb nonself-transmissible plasmid. Such coexistence has the potential to allow the generation of new, hybrid bla
IMP variants by homologous recombination. The bla
IMP-69-carrying IncC plasmid belonged to the core-genome plasmid multilocus sequence typing (cgPMLST) 3.5 type. We found that cgPMLST 3.5 IncC plasmids have been circulating worldwide for decades and may represent a common vehicle mediating the spread of antimicrobial resistance.
Publisher
Oxford University Press
Subject
