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Covalently closed circular DNA activity in HBV infection
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Covalently closed circular DNA activity in HBV infection
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Journal Article
Covalently closed circular DNA activity in HBV infection
2011
Overview
Covalently closed circular DNA (cccDNA) is a viral minichromosome from which HBV RNA replication intermediate (pregenomic RNA) is transcribed. Intrahepatic contents of cccDNA is lower in HBeAg-negative CHB compared to HBeAg-positive CHB, but cccDNA persists even after HBsAg loss (occult HBV infection). There are evidences indicating that activity of cccDNA differ in different stages of CHB infection. Possible genetic and epigenetic mechanisms responsible for the modulation of cccDNA activity are discussed in this review.
Publisher
대한간학회
