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The synthetic compound 20-hydroxy-2,4,60-trimethoxychalcone overcomes P-glycoprotein-mediated multi-drug resistance in drug-resistant uterine sarcoma MES-SA/DX5 cells
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The synthetic compound 20-hydroxy-2,4,60-trimethoxychalcone overcomes P-glycoprotein-mediated multi-drug resistance in drug-resistant uterine sarcoma MES-SA/DX5 cells
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The synthetic compound 20-hydroxy-2,4,60-trimethoxychalcone overcomes P-glycoprotein-mediated multi-drug resistance in drug-resistant uterine sarcoma MES-SA/DX5 cells
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Journal Article
The synthetic compound 20-hydroxy-2,4,60-trimethoxychalcone overcomes P-glycoprotein-mediated multi-drug resistance in drug-resistant uterine sarcoma MES-SA/DX5 cells
2015
Overview
The antitumor activity of a novel syntheticchalcone derivative, 20-hydroxy-2,4,60-trimethoxychalcone(1H3MC), was evaluated using the multi-drug-resistanthuman uterine sarcoma MES-SA/Dx5 cells. Treatmentwith 1H3MC reduced P-glycoprotein expression in a timedependentmanner and inhibited MES-SA/Dx5 cell proliferation.
Cisplatin alone had no effect on cell viability, butcombined treatment with cisplatin and 1H3MC exhibitedsynergistic cytotoxicity. Furthermore, the combination ofcisplatin and 1H3MC synergistically cleaved both caspase-3 and its substrate protein, poly(ADP-ribose) polymerase,which resulted in the fragmentation of genomic DNA, ahallmark of apoptosis. These results suggest that 1H3MC isa promising adjuvant agent for overcoming P-glycoproteinmediatedmulti-drug resistance in cancer cells. KCI Citation Count: 4
Publisher
한국응용생명화학회
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