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A case of hemoglobin Hiroshima (beta146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA^sub 1c
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A case of hemoglobin Hiroshima (beta146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA^sub 1c
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Journal Article
A case of hemoglobin Hiroshima (beta146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA^sub 1c
2012
Overview
Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA^sub 1c^ level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine [arrow right] aspartic acid). Caution should be exercised when diagnosing erythremia.[PUBLICATION ABSTRACT]
Publisher
Springer Nature B.V
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