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IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer

by Ugel, Stefano , Bronte, Vincenzo , Zanovello, Paola , Matera, Lina , Brutti, Nadia , Mazzocco, Marta , Picchio, Maria Cristina , Cestari, Tiziana , Riviera, Anna Pia , Barbieri, Ottavia , Cingarlini, Sara , Tridente, Giuseppe , Sartoris, Silvia , Pasetto, Matteo , Innamorati, Giulio , Krampera, Mauro , Colombatti, Marco , Martini, Matteo , Mosna, Federico , Testi, Maria Grazia

in Experiments / Immune response / Immune system / Immunization / Plasmids / Prostate cancer / T cell receptors / Tumors

2010

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IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer

in Experiments / Immune response / Immune system / Immunization / Plasmids / Prostate cancer / T cell receptors / Tumors

2010

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IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer

in Experiments / Immune response / Immune system / Immunization / Plasmids / Prostate cancer / T cell receptors / Tumors

2010

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Journal Article

IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer

Ugel, Stefano,

Bronte, Vincenzo,

Zanovello, Paola,

Matera, Lina,

Brutti, Nadia,

Mazzocco, Marta,

Picchio, Maria Cristina,

Cestari, Tiziana,

Riviera, Anna Pia,

Barbieri, Ottavia,

Cingarlini, Sara,

Tridente, Giuseppe,

Sartoris, Silvia,

Pasetto, Matteo,

Innamorati, Giulio,

Krampera, Mauro,

Colombatti, Marco,

Martini, Matteo,

Mosna, Federico,

Testi, Maria Grazia

2010

Overview

De novoexpression of B7-1 impaired tumorigenicity of TRAMP-C2 mouse prostate adenocarcinoma (TRAMP-C2/B7), but it did not elicit a protective response against TRAMP-C2 parental tumor, unless afterin vitrotreatment with IFN-γ. TRAMP-C2 cells secrete TGF-β and show low MHC-I expression. Treatment with IFN-γ increased MHC-I expression by induction of some APM components and antagonizing the immunosuppressant activity of TGF-β. Thus, immunization with TRAMP-C2/B7 conferred protection against TRAMP-C2-derived tumors in function of the IFN-γ-mediated fine-tuned modulation of either APM expression or TGF-β signaling. To explore possible clinical translation, we delivered IFN-γ to TRAMP-C2 tumor site by means of genetically engineered MSCs secreting IFN-γ.

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Elsevier Limited

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