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Inhibiting mitochondrial beta-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain
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Inhibiting mitochondrial beta-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain
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Inhibiting mitochondrial beta-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain
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Journal Article
Inhibiting mitochondrial beta-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain
2014
Overview
Schönfeld and Reiser recently hypothesized that fatty acid [beta]-oxidation is a source of oxidative stress in the brain. To test this hypothesis, we inhibited brain mitochondrial [beta]-oxidation with methyl palmoxirate (MEP) and measured oxidative polyunsaturated fatty acid (PUFA) metabolites in the rat brain. Upon MEP treatment, levels of several nonenzymatic auto-oxidative PUFA metabolites were reduced with few effects on enzymatically derived metabolites. Our finding confirms the hypothesis that reduced fatty acid [beta]-oxidation decreases oxidative stress in the brain and [beta]-oxidation inhibitors may be a novel therapeutic approach for brain disorders associated with oxidative stress.
Publisher
Sage Publications Ltd
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