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oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-gamma, CXCL16, and ADAM10
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oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-gamma, CXCL16, and ADAM10
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Journal Article
oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-gamma, CXCL16, and ADAM10
2014
Overview
Previous studies have shown that lipid accumulation plays an important role in the pathogenesis and development of glomerular sclerosis. oxLDL caused damage in renal mesangial cells, endothelial cells, and podocytes, and podocytes might be the major victim of oxLDL insult. However, the regulatory mechanism of how oxLDL induces the damage of podocytes remains to be elucidated. In this study, oil red staining was used to investigate the lipid accumulation in podocytes. Moreover, the effects of CXCL16 antibody, IFN-γ, and ADAM10 inhibitor on oxLDL intake and CXCL16 expression were also explored to elucidate the regulatory factors of lipid accumulation in podocytes.[PUBLICATION ABSTRACT]
Publisher
Springer Nature B.V
Subject
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