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Parameter estimation performance for sigmoid emaxmodels in exposure-response Relationship
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Journal Article
Parameter estimation performance for sigmoid emaxmodels in exposure-response Relationship
2015
Overview
A total of 70 scenarios with 100 subjects were simulated and estimated 100 times applying one compartment PK model with first-order absorption and sigmoid Emax model using SSE (Stochastic simulation and estimation) of PSN (Perl-speaks-NONMEM) and first order conditional estimation with interaction (FOCE-I) method in NONMEM (version 7.2).The bias and precision of the parameter estimates in each scenario were assessed using relative bias and relative root mean square error.
Publisher
Elsevier Limited
Subject
