Asset Details
Do you wish to reserve the book?
Examining the Therapeutic Potential of Deep Brain Stimulation in a Preclinical Model of Post-Traumatic Stress Disorder
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Examining the Therapeutic Potential of Deep Brain Stimulation in a Preclinical Model of Post-Traumatic Stress Disorder
Do you wish to request the book?
Examining the Therapeutic Potential of Deep Brain Stimulation in a Preclinical Model of Post-Traumatic Stress Disorder
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Dissertation
Examining the Therapeutic Potential of Deep Brain Stimulation in a Preclinical Model of Post-Traumatic Stress Disorder
2015
Overview
Considerable progress has been made in the understanding and treatment of Post-Traumatic Stress Disorder (PTSD). However, up to 30% of patients fail to achieve meaningful relief despite multiple treatment attempts. Animal models play an important role in the development of new treatment strategies. This thesis describes a preclinical model of PTSD in which animals displaying impaired fear extinction also exhibit behavioural and endocrine abnormalities similar to those described in PTSD. The model is then implemented to examine the translational potential of Deep Brain Stimulation (DBS) for the treatment of PTSD. A frontline pharmacological intervention, Fluoxetine, is also tested using the model. Chronic DBS of the infralimbic cortex, but not acute DBS or chronic Fluoxetine, was shown to attenuate fear expression to a conditioned aversive cue and reduce anxiety behaviours in PTSD-like rats. These findings demonstrate the translational potential of DBS for the treatment of severe, intractable PTSD.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9781339300528, 1339300524
