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Recurrent Respiratory Infections Revealing CD8alpha Deficiency
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Journal Article
Recurrent Respiratory Infections Revealing CD8alpha Deficiency
2015
Overview
CD8A encodes the CD8[alpha] chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.
Publisher
Springer Nature B.V
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