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The Role of Suppressor of Fused During Murine Cerebellar Morphogenesis
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The Role of Suppressor of Fused During Murine Cerebellar Morphogenesis
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Dissertation
The Role of Suppressor of Fused During Murine Cerebellar Morphogenesis
2013
Overview
Suppressor of Fused (SuFu) is an intracellular mediator of the Hedgehog signaling pathway with diverse biological roles, including a tumour suppressor function. Recent data suggest an essential role for this gene in cell differentiation in various tissues and cancers. Despite its known role as a tumour suppressor in medulloblastoma, a neuroectodermal tumour of cerebellar origin, the functional importance of SuFu in the developing cerebellum remains unknown. In this thesis, using in vivo conditional knockout approaches and in vitro assays, I present evidence for a novel requirement for SuFu during mid-hindbrain specification, cerebellar patterning and cell differentiation. (Abstract shortened by UMI.)
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