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Study of active secondary metabolites of Streptomyces levis isolated from north west soils of Iran and their in vitro and in vivo antibacterial effects
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Study of active secondary metabolites of Streptomyces levis isolated from north west soils of Iran and their in vitro and in vivo antibacterial effects
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Journal Article
Study of active secondary metabolites of Streptomyces levis isolated from north west soils of Iran and their in vitro and in vivo antibacterial effects
2017
Overview
Background: Streptomyces l vis is a member of Actinomycetes family. Chemical compounds extracted from this bacterium have been used as antibiotics, anti-tumoral, anti-bacterial, anti-fungal, antiviral, anticancer factors. The purpose of this study‚ was to investigate different metabolites of Streptomyces strains isolated from north west soils, of Iran and antimicrobial effects of them.Methods: The soil samples were taken from north west of Iran in 2010. The isolated bacteria were purified and identified by conventional methods. The metabolites of this bacterium were extracted by 7 different solvents (diethyl ether, dichloromethane, hexane, ethyl acetate, chloroform, methanol and water). The antimicrobial effects of metabolites were tested by disk agar diffusion method on Gram-positive and Gram- negative bacteria. The metabolites with antibacterial effects were analyzed by gas chromatography-mass spectrometry (GC-MS).Results: Metabolites produced from diethyl ether solvent affected Gram- positive and Gram- negative strains and 15 different compounds identified in the active metabolite of the bacterium. The main ingredients were: Docosanoic acid, methyl ester (11.578%), 9-12-octadecadienoic acid (2.961%), 5-Tetracosenois acid, methyl ester (8.389%), Bis (2-ethylhexyl) phthalate (2.153%), and D-alpha-Tocopherol (0.959%).Conclusion: Results of this study showed that docosanoic acid, methyl ester (11.578%) and 5-tetracosenois acid methyl ester (8.389%), were the main metabolites of Streptomyces levis isolated from north west soils of Iran. Antimicrobial effects of extracts could be due to the presence of 1, 2-benzene dicarboxylic acid diisooctyl ester compounds and bis (2-ethylhexyl) phthalate in the metabolite.
Publisher
Tabriz University of Medical Sciences
