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Itraconazole or Amphotericin B for Talaromycosis
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Itraconazole or Amphotericin B for Talaromycosis
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Journal Article
Itraconazole or Amphotericin B for Talaromycosis
2017
Overview
Itraconazole is a weakly basic drug, and dissolution of the drug is pH-dependent; thus the drug requires an acidic gastric environment for adequate absorption.1 Numerous studies have documented substantial variation in itraconazole exposure owing to the effect of food, interaction with coadministered drugs, and adherence.2 Guidelines recommend assessment of the exposure to itraconazole through therapeutic drug monitoring when the drug is used for treatment of systemic fungal diseases,3 including talaromycosis.4 Le et al. do not report on the exposure to itraconazole, but because capsules were used, underdosing of itraconazole might have been a factor in the lower response rate.
Publisher
Massachusetts Medical Society
Subject
