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NF-kappaB inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells
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NF-kappaB inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells
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Journal Article
NF-kappaB inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells
2000
Overview
Epstein-Barr virus (EBV) transforms B lymphocytes into lymphoblastoid cell lines usurping the Notch and tumor necrosis factor receptor pathways to effect transcription including NF-kappaB activation. To determine whether NF-kappaB activity is essential in the growth and survival of EBV-transformed lymphoblastoid cell lines, a nondegradable IkappaBalpha mutant was expressed under tetracycline regulation.
Publisher
National Academy of Sciences
Subject
