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Modified Hopkins conditioning may improve donor engraftment for sickle cell disease
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Modified Hopkins conditioning may improve donor engraftment for sickle cell disease
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Journal Article
Modified Hopkins conditioning may improve donor engraftment for sickle cell disease
2018
Overview
An altered version of the Hopkins conditioning regimen may lead to more stable donor engraftment without severe toxicity among patients with sickle cell disease who undergo haploidentical hematopoietic stem cell transplantation, according to study data. \"Less than 20% of sickle cell disease patients will have an HLA-matched donor and alternative stem cell sources, such as haploidentical donors, can expand the donor pool,\" Santosh L. Saraf, MD, assistant professor of medicine at University of Illinois at Chicago, told HemOnc Today. The other eight patients received a modified version of the Hopkins protocol - 30 mg/m2 fludarabine, 14.5 mg/kg cyclophosphamide, 3 Gy total body irradiation, 0.5 mg/kg antithymocyte globulin, 50 mg/kg after transplant cyclophosphamide and infused mobilized peripheral blood stem cells.
Publisher
SLACK INCORPORATED
Subject
