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Assessing Cerebral Oxygen Supply and Demand in Sickle Cell Anemia using MRI
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Assessing Cerebral Oxygen Supply and Demand in Sickle Cell Anemia using MRI
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Dissertation
Assessing Cerebral Oxygen Supply and Demand in Sickle Cell Anemia using MRI
2017
Overview
This thesis explores MRI measurements of cerebral oxygen supply and demand in subjects with sickle cell disease. I hypothesize that uncoupling of cerebral oxygen supply and demand occurs in patients with sickle cell disease due to pathophysiology. To test this hypothesis, this thesis goes on to validate MR cerebral oxygen supply and demand methods including Phase Contrast, Arterial Spin Labeling and T2 Relaxation Under Spin Tagging.
