Journal Article

Regional homogeneity on resting state fMRI in patients with uremic restless legs syndrome / 尿毒症不宁腿患者静息态脑功能磁共振局部一致性研究

LI, Peng, DING Dun, ZHANG, Ming, Jian-xin, GUO, Xue-ying, MA

2017

Overview

Objective: To study neuromechanism for uremic restless syndrome (URLS), functional MRI (fMRI) analysis and were used to explor main activity. Methods: Resting state functional magnetic resonance imaging (MRI) was performed on 29 patients with uremic restless legs syndrome and 25 healthy controls. The values of the regional homogeneity (ReHo) of the two groups were calculated and analyzed statistically. Result As compared with the control group, patients with uremic restless legs syndrome showed emotional and mental abnormality. Increased ReHo values in bilateral supplementary motor area, bilateral thalamus, left insular lobe, left hippocampus (P<0.05), and decreased ReHo values in anterior cingulate gyrus, bilateral posterior central gyrus, right amygdala were found in patients with uremic restless legs syndrome (P<0.05). The severity score of RLS was respectively positively correlated with dialysis duration (r=0.57, P=0.002), PTH level (r=0.419, P=0.033) BAI (r=0.528, P=0.006), and BDI (r=0.567, P=0.003). Co

• Publisher: Xi'an Jiaotong University
• Subject: Hemodialysis / NMR / Nuclear magnetic resonance / Restless legs syndrome / Sleep deprivation