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Serum MMP-9 and TIMP-1 levels in patients with chronic kidney disease after oxymatrine treatment / 氧化苦参碱对慢性肾脏病患者血清MMP-9和TIMP-1的影响
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Serum MMP-9 and TIMP-1 levels in patients with chronic kidney disease after oxymatrine treatment / 氧化苦参碱对慢性肾脏病患者血清MMP-9和TIMP-1的影响
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Serum MMP-9 and TIMP-1 levels in patients with chronic kidney disease after oxymatrine treatment / 氧化苦参碱对慢性肾脏病患者血清MMP-9和TIMP-1的影响
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Journal Article
Serum MMP-9 and TIMP-1 levels in patients with chronic kidney disease after oxymatrine treatment / 氧化苦参碱对慢性肾脏病患者血清MMP-9和TIMP-1的影响
2008
Overview
目的 观察氧化苦参碱对慢性肾脏病(CKD)患者血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制因子-1(TIMP-1)的影响,探讨其在肾间质纤维化发生发展过程中的作用和治疗价值.方法 选取健康对照者10例、慢性肾脏病患者40例,根据肾小球滤过率(GFR)分为轻度肾损害组(GFR＜90 mL/min·1.73 m2, CKDⅠ)和中、重度肾损害组(GFR＜60 mL/min·1.73 m2 ,CKDⅡ),再分层随机抽样,分为常规治疗组和氧化苦参碱组.利用双抗体夹心酶联免疫吸附法分别检测各组治疗前后血清MMP-9和TIMP-1含量,采用t检验比较两组MMP-9和TIMP-1水平的差异.结果 经氧化苦参碱干预后,TIMP-1水平显著低于常规治疗组,而MMP-9水平则显著高于常规治疗组(P＜0.05).结论 氧化苦参碱可下调TIMP-1水平,恢复MMP-9水平,保持MMP-9/TIMP-1平衡,减少细胞外基质(ECM)沉积,防止肾间质纤维化.
Publisher
Xi'an Jiaotong University
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