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Chemically Modified Monolayer Surfaces Influence Valvular Interstitial Cell Attachment and Differentiation for Heart Valve Tissue Engineering
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Chemically Modified Monolayer Surfaces Influence Valvular Interstitial Cell Attachment and Differentiation for Heart Valve Tissue Engineering
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Dissertation
Chemically Modified Monolayer Surfaces Influence Valvular Interstitial Cell Attachment and Differentiation for Heart Valve Tissue Engineering
2018
Overview
As a cell mediated-process, valvular heart disease (VHD) results in significant morbidity and mortality world-wide. In the US alone, valvular heart disease VHD is estimated to affect 2.5% of the population with a disproportionate impact on an increasing elderly populous. It is well understood that the primary driver for valvular calcification is the differentiation of valvular interstitial cells (VICs) into an osteoblastic-like phenotype. However, the factors leading to the onset of osteoblastic-like VICs (obVICs) and resulting calcification are not fully understood and a more complete characterization of VIC differentiation and phenotypic change is required before treatment of valve disease or growth of tissue engineered heart valves (TEHVs) can be realized. By investigating the microenvironmental cues at the cell-material interface, surface chemistry, protein adhesion, and integrin expression we have identified cell-material signaling that may be responsible for heart valve tissue calcification as well as healthy in vitro growth environments. A three-dimensional hydrogel system was developed for the study of VICs in a more physically relevant cell culture system.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9781392029299, 1392029295
