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Spatiotemporal Coordination of Signaling at Single Molecule Resolution
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Dissertation
Spatiotemporal Coordination of Signaling at Single Molecule Resolution
2020
Overview
Advances in live-cell single-molecule imaging and modeling over the past decade have invited the closer study of biological structure and dynamics at the nanoscale. The higher resolution of these single-molecule experiments results in finely-grained datasets that can feed detailed quantitative models. Likewise, single-molecule models can account for microscopic details such as noise and heterogeneity inherent to diffusional and chemical processes, which are often neglected in models based on bulk concentrations. Examining microscale biological structures at single molecule resolution in living cells has led to new findings, such as the dynamic regulation of nanoscale structure. I cover three topics from the perspective of single molecules. Chapters 1-3 are on modeling the spatiotemporal coordination of both spontaneous and pheromone-guided yeast polarity establishment. Chapter 4 is on computational modeling and analysis for a technique called Binder/Tag, which we applied to study the conformational dynamics of the protein Src kinase in living cells. Chapter 5 is on modeling clustering-mediated activation of immunoreceptors, using the phagocytic receptor FcγRIIA as a prototypical example.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798641556635
