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The HSPG Syndecan is a core organizer of cholinergic synapses in C. elegans
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The HSPG Syndecan is a core organizer of cholinergic synapses in C. elegans
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Paper
The HSPG Syndecan is a core organizer of cholinergic synapses in C. elegans
2020
Overview
C. elegans, is absolutely required for the synaptic clustering of homomeric α7-like N-acetylcholine receptors (AChR) and regulates the synaptic content of heteromeric L-AChRs. SDN-1 is concentrated at neuromuscular junctions (NMJs) by the neurally-secreted synaptic organizer Ce-Punctin/MADD-4, which also activates the transmembrane netrin receptor DCC. Those cooperatively recruit the FARP and CASK orthologues that localize N-AChRs at cholinergic NMJs through physical interactions. Therefore, SDN-1 stands at the core of the cholinergic synapse organization by bridging the extracellular synaptic determinants to the intracellular synaptic scaffold that controls the postsynaptic receptor content. Competing Interest Statement The authors have declared no competing interest. Footnotes * ↵c Co-first authors
Publisher
Cold Spring Harbor Laboratory Press
