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Study of Effect of Iron Deficiency Anaemia on Glycation of Hemoglobin in Non Diabetics
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Study of Effect of Iron Deficiency Anaemia on Glycation of Hemoglobin in Non Diabetics
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Dissertation
Study of Effect of Iron Deficiency Anaemia on Glycation of Hemoglobin in Non Diabetics
2015
Overview
Introduction: Glycated hemoglobin (HbA1c) is commonly used for monitoring glycemic control and as predictor of diabetes complications. Recently, HbA1c has also boon recommended as a diagnostic test for diabetes mellitus by the American Diabetes Association (ADA). Anaemia is cited as major confounding factor to this use. Elevated HbA1c levels are documented in Iron Deficiency Anaemia (IDA) patients without any history of diabetes. The aim of this study is to determine the effect of IDA on the HbA1c levels in non-diabetic patients. Materials: 63 non-diabetic, anaemic patients and 63 age-matched healthy subjects were enrolled in this study. The patients with glucose tolerance abnormalities (impaired glucose tolerance or diabetes mellitus), hemoglobinopathies, hemolytic anaemia, chronic alcohol ingestion, chronic renal failure and pregnant females were excluded from the study. Complete hemogram with peripheral smear, serum ferritin, FBS, PLBS and HbA1c levels were measured in all the subjects. Observations: The mean HbA1c (6.13±0.6%) level in the patients with IDA was higher than that in the control group (5.12±0.5%) (p<0.001). There were no differences in the levels of FBS, PLBS between both groups (p>0.05). The hemoglobin, serum ferritin, FBS, PLBS and the HbA1c levels were normal in the control group (p > 0.05). Conclusion; It was found that Iron Deficiency Anaemia was common among the reproductive age group women. It was associated with shift in the HbA1c levels to higher side, primarily between 6premenopausal females, who are at increased risk of iron deficiency; the concomitant increase in HbA1c values in these patients due to iron deficiency will move the diagnosis of pre-diabetes to diabetes. It is hence prudent to rule out IDA before making a therapeutic decision, based on the HbA1c levels..0% and 6.5%. As the incidence and prevalence of young onset obesity is increasing, many of whom are child bearing and
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798708736864
