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Natural Killer Cells in Adoptive Cell Immunotherapy for Cancer
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Journal Article
Natural Killer Cells in Adoptive Cell Immunotherapy for Cancer
2022
Overview
Tumor cells downregulate MHC class I molecule expression in an effort to evade T cell responses and upregulate activating ligands that are induced by stress, such as DNA damage or malignant transformation. [...]we offer a viewpoint on the potential and difficulties that lie ahead as we work to combat solid tumours, protect immune effector cells from the suppressive pressures present in the tumour microenvironment, and develop tools to monitor and address unintended safety concerns. Memory-like function in NK cells These cells were interestingly able to reawaken after a dormant period upon cytokine stimulation or activation of activating receptors and displayed an increased IFN response mimicking the memory-like characteristics of adaptive immune cells. NK cell source and donor selection The viability of autologous NK cell treatment applications is limited because cancer patients' NK cells frequently have a defective phenotype indicated by altered gene expression profiles and reduced cytotoxic capability.
Publisher
DRUNPP Association
Subject
