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Modelling the Effects of β-Arrestin-Mediated Signaling in Cortical D2R Expressing Neurons Using Crispr-Cas9
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Modelling the Effects of β-Arrestin-Mediated Signaling in Cortical D2R Expressing Neurons Using Crispr-Cas9
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Modelling the Effects of β-Arrestin-Mediated Signaling in Cortical D2R Expressing Neurons Using Crispr-Cas9
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Dissertation
Modelling the Effects of β-Arrestin-Mediated Signaling in Cortical D2R Expressing Neurons Using Crispr-Cas9
2023
Overview
Dopamine dysregulation is implicated in psychiatric disorders such as Schizophrenia, Bipolar Disorder, and Major Depression. These conditions are managed by antipsychotics, which can exert their effects through G-protein-mediated or β-arrestin-mediated signaling pathways, which may each regulate different behavioral responses. While the principles of biased signaling provide an attractive strategy for developing novel therapeutics for psychiatric conditions, older methods for surveying the contributions of β-arrestin pathway to behavior are limited. Therefore, this study sought to use CRISPR-Cas9 to generate a model for exploring whether loss of β-arrestin in a regional and cell-type-specific manner could affect psychomotor, emotional, cognitive, and social behaviors.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798377616429
