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\Stuck in the Middle with You\: intermediate cell states are not always in transition
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Journal Article
\Stuck in the Middle with You\: intermediate cell states are not always in transition
2023
Overview
The era of single-cell multiomics has led to the identification of lung epithelial cells with features of both alveolartype 1 (AT1) and alveolartype 2 (AT2) pneumocytes, leading many to inferthat these cells are a distinct cell type in the process of transitioning between AT2 and AT1 cells. In this issue of the JCI, Wang and colleagues demonstrated that many so-called \"transitional cells\" do not actually contribute to functional repair. The findings warrant a reimagining of these cells as existing in a nondirectional, intermediate cell state, ratherthan movingthrough a transitory process from one cell type to another. We look forward to further exploration of diverse cell state expression profiles and a more refined examination of hallmark gene function beyond population labeling.
Publisher
American Society for Clinical Investigation
Subject
