Journal Article

Histopathological study of epidermal& dermal changes in lesional&perilesional biopsies of psoriasis cases at a tertiary center- An Original Research

Divyasree, Kummari, Vidyarani, D

2022

Overview

Background: Psoriasisis a chronic disease of the skin of unknown etiology that is characterised bychronic relapsing nature and variable clinical features. Since histopathological study gives the exact diagnosis of psoriasis & can differentiate it from other histological mimics, present study was aimed to study histopathological features of epidermal and dermal changes in lesionaland perilesional biopsies of psoriasis cases at a tertiary center.Materials and Methods:Present study was single-center, prospective, observational study, conducted in patients with clinical features of psoriasis, not received treatment for the past, skin biopsies were taken from both lesional& perilesional areas of psoriatic patients, H & E staining was done. Results:Among 52 cases, majority of patients were from the age group 31-40 years (40.3 %), and maleto female patient ratio was 2.7:1.Clinically, common features were macules/papules/plaques (100 %), moderate-severe itching (80.7%), nail involvement (61.5 %), nail pitting (40.3%), subungual hyperkeratosis (17.3%), nail discolouration (3.84%), Koebner phenomenon (23%), Auspitz sign (75%). Among 8 cases of early lesions, common features observed were parakeratosis (100%) mild to moderate acanthosis (100%), dilated capillaries and perivascular cellular infiltrate (100%), thinning of supra papillary plate (50%), Munro micro abscess (50%), spongiosis (37.5%).

• Publisher: NeuroQuantology
• Subject: Biopsy / Capillaries / Itching / Lesions / Psoriasis