Asset Details
Do you wish to reserve the book?
Exploring the Impact of Bioactive Compounds on Necrotizing Enterocolitis (NEC) In Vivo (Gallus gallus)
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Exploring the Impact of Bioactive Compounds on Necrotizing Enterocolitis (NEC) In Vivo (Gallus gallus)
Do you wish to request the book?
Exploring the Impact of Bioactive Compounds on Necrotizing Enterocolitis (NEC) In Vivo (Gallus gallus)
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Dissertation
Exploring the Impact of Bioactive Compounds on Necrotizing Enterocolitis (NEC) In Vivo (Gallus gallus)
2023
Overview
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease in premature infants and a leading cause of death in neonates (1-7% in the US). NEC is caused by opportunistic bacteria, which cause gut dysbiosis and inflammation, ultimately resulting in intestinal necrosis. Current NEC interventions include broad-spectrum antibiotic treatment and/or small intestine surgical removal, which can have harmful effects. Even with surgical intervention, NEC global mortality rates are 6-9% (1-7% in the US). Various potential animal NEC models have been utilized to study the disease; however, the disease, sensitive in vivo NEC biomarkers, and possible interventions remain undefined. Crop-based bioactive compounds have previously been shown to possess anti-inflammatory properties and positively modulate the gut microbiome, providing a viable alternative for NEC treatment. Chapter 1 summarizes NEC pathology and essential background on the disease. Chapter 2 systematically reviews the literature on NEC dietary bioactive compounds utilized in vivo from the last six years. Chapter 3 discusses a new in vivo model for NEC and the efficacy of the Gallus gallus model for NEC. Chapter 4 investigates the benefits and nutritional effects of catechin and 2 short-chain fatty acid alternatives on improving intestinal functionality and morphology and altering the gut microbiome in vivo. Chapter 5 investigates nicotinamide riboside and 2 other short-chain fatty acid derivatives on the intestinal function and morphology in ovo. To conclude, Chapter 6 highlights significant findings in chapters 2-5 and suggests future.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798381414660
