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Erythropoetin in der Strahlentherapie
by
Dunst, J
, Rades, D
, Metzen, E
2007
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Erythropoetin in der Strahlentherapie
by
Dunst, J
, Rades, D
, Metzen, E
2007
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Journal Article
Erythropoetin in der Strahlentherapie
2007
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Overview
Anämie ist ein wichtiger und unabhängiger Prognosefaktor bei Patienten mit Plattenepithelkarzinomen im Kopf-Hals-Bereich, insbesondere bei definitiver Strahlentherapie. Dies beruht wahrscheinlich auf verschiedenen Ursachen, von denen die Verstärkung einer Tumorhypoxie durch Anämie ein wichtiger Faktor ist. Im Tiermodell kann man durch Anämiekorrektur mittels Erythropoetinen die Strahlenempfindlichkeit verbessern. Der Einsatz von Erythropoetin bei Kopf-Hals-Tumoren ist deshalb logisch und konsequent. Allerdings zeigen die bisherigen klinischen Ergebnisse keine Vorteile hinsichtlich des Überlebens.
Publisher
Springer Nature B.V
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