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A COMPARISON OF AMPLITUDE AND LATENCY MEASURES OF THE P300 AUDITORY EVENT-RELATED POTENTIAL RECORDED FROM CLOSED HEAD-INJURED AND NORMAL MALES (BRAIN-INJURY, EVOKED-POTENTIAL)
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A COMPARISON OF AMPLITUDE AND LATENCY MEASURES OF THE P300 AUDITORY EVENT-RELATED POTENTIAL RECORDED FROM CLOSED HEAD-INJURED AND NORMAL MALES (BRAIN-INJURY, EVOKED-POTENTIAL)
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A COMPARISON OF AMPLITUDE AND LATENCY MEASURES OF THE P300 AUDITORY EVENT-RELATED POTENTIAL RECORDED FROM CLOSED HEAD-INJURED AND NORMAL MALES (BRAIN-INJURY, EVOKED-POTENTIAL)
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Dissertation
A COMPARISON OF AMPLITUDE AND LATENCY MEASURES OF THE P300 AUDITORY EVENT-RELATED POTENTIAL RECORDED FROM CLOSED HEAD-INJURED AND NORMAL MALES (BRAIN-INJURY, EVOKED-POTENTIAL)
1986
Overview
Closed head injury (CHI) frequently results in cognitive deficits (e.g., attention and concentration). The P300 event-related potential (ERP) has been suggested for measuring cognition after CHI. This cortically-evoked potential has been associated with neuro-electrical events believed to underly cognition. Differences in amplitude and latency measures of the ERP have been demonstrated with patients with dementia and schizophrenia. Curry (1980) and Papanicolaou et al. (1984) investigated differences in the P300 ERP measured from CHI subjects and normals. They concluded that the P300 is associated with cognitive status. This study was proposed to further evaluate the ERP morphology in relation to cortical behavior and cognitive functioning following CHI. Questions posed included: Do latency and amplitude measures of the P300 ERP differ between CHI and normal subjects? Is there a correlation between latency and amplitude measures of the P300 component? Fifteen CHI and 15 normal males participated in this study. Auditory ERPs were measured in an 'oddball' task paradigm involving the presentation of a random series of tones: 85% were 1000 Hz and 15% were 2000 Hz. Subjects listened to the tones and kept track of the total number of infrequently occurring tones. Auditory ERPs were recorded and peak latency and amplitude measures were analyzed using the Nicolet Pathfinder II. Significant differences between the CHI and normal subjects were revealed using a two-factor repeated measures analysis of variance. A moderate correlation was found between latency and amplitude measures. This study demonstrated differences in electro-cortical functioning between CHI and normal males. As a group, CHI subjects showed significantly prolonged P300 peak latencies and diminished amplitudes compared with normals, suggesting differences in both the patterns and rates of cognitive processes considered responsible for generating the P300 ERP. Different neurophysiological processes believed to contribute to the amplitude and latency measures of the P300 waveform, thereby accounting for the correlational findings. Future research should include the evaluation of CHI patients ranging in severity of injury. Increasing and varying task demands would also yield important information. Another valuable direction for research would be the longitudinal, serial evaluation of CHI patients.
